effects of endogenous production and exogenous administration of h2s on gastric acid secretion in rats

Authors

seyyed ali mard physiology research center and dept. physiology, the school of medicine, ahvaz jundi shapur university of medical sciences, ahvaz, iran

maryam maleki physiology research center and dept. physiology, the school of medicine, ahvaz jundi shapur university of medical sciences, ahvaz, iran

mohammad kazem gharib naseri physiology research center and dept. physiology, the school of medicine, ahvaz jundi shapur university of medical sciences, ahvaz, iran

alihosein saberi

abstract

introduction: recently, hydrogen sulfide has been introduced as the third gas that acts as a transmitter. it has many physiological and pharmacological roles in the human body. the aim of the present study was to investigate the effect of exogenously administered and endogenously produced h2s on the basal and distention-induced gastric acid secretion in rats. methods: forty-nine male wistar rats (150-200 g) were randomly assigned into 7 groups (7 rats per group). to evaluate the effect of h2s on the basal acid secretion, three groups of animals received an iv bolus of nahs, a h2s donor, at the doses of 20, 40 or 80 μg/kg. the effects of iv nahs 20, 40 or 80 μg/kg were also investigated on distention-induced gastric acid secretion in other three groups. in order to evaluate the effect of endogenously produced h2s on distention-induced gastric acid secretion, one group of animals received iv propargylglycine (pag), a cystathionine-γ-lyase inhibitor, 100 mg/kg. results: nahs decreased the basal and distention-induced gastric acid secretion in a dose-dependent manner (p<0.01). pag increased the gastric output in response to distention compared to the control group (p<0.001). conclusion: our results showed that both exogenous administration and endogenous production of h2s decrease the gastric acid output. also, the findings of the present study suggest that endogenously produced h2s has a modulatory effect on stimulated gastric acid output similar to nitric oxide (no).

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Effects of endogenous production and exogenous administration of H2S on gastric acid secretion in rats

Introduction: Recently, hydrogen sulfide has been introduced as the third gas that acts as a transmitter. It has many physiological and pharmacological roles in the human body. The aim of the present study was to investigate the effect of exogenously administered and endogenously produced H2S on the basal and distention-induced gastric acid secretion in rats. Methods: Forty-nine male Wistar...

full text

study the effects of low level laser diode on no production and healing of diabetic and cortisone acetate and normal wounded sd rats

nitric oxide (no) is a small molecule synthesized by most of mammalian cells with diverse biological activities including vasodilatation, host defense and wound healing. impaired wound healing is a common occurrence among diabetics and patients receiving glucocorticoid therapy. on the other hand the application of laser in biomedical area have been increased. thus, the current studies were desi...

15 صفحه اول

Effect of Esophageal Distention on Basal and Stimulated Gastric Acid Secretion in Rats

It is well established that the esophageal distention (ED) leads to gastric relaxation, partly by vago-vagal reflex, but till now, the effect of ED on gastric acid secretion has not been investigated. The aim of this study was to investigate the effect of ED on basal and stimulated gastric acid secretion. Methods: Adult male Wistar rats (200-240 g) were deprived of food but not the water 24 h b...

full text

the effects of high non fibrous carbohydrates diet on milk production, inflammation and molecular mechanism of innate immunity in lactating dairy cows

پژوهش حاضر با هدف بررسی اثر جیره حاوی کربوهیدراتهای غیرالیافی زیاد و بروز التهاب در گاوهای شیرده در دو آزمایش جداگانه انجام شد. در آزمایش اول 20 رأس گاو مبتلا به ورم پستان از دو گروه کم تولید و پرتولید (هر کدام 10 رأس) و 20 رأس گاو سالم از دو گروه کم تولید و پرتولید (هر کدام 10 رأس) انتخاب شدند. همه گاوها در دوره دوم و یا سوم شیردهی و در روزهای 80-120 پس از زایش بودند. میانگین تولید شیر در گروه...

The effect of bromocriptine on basal and histamine-stimulated gastric acid secretion in anesthetized rats

Introduction: The protective and antisecretory effects of dopamine agonists on the stomach have been already reported, but the effect of bromocriptine (D2 dopamine agonist) on histamine stimulated gastric acid secretion (GAS) needs to be investigated. Methods: For gastric sampling, animals were anesthetized and a polyethylen tube was introduced into the stomach through esophagus. A cannula ...

full text

My Resources

Save resource for easier access later


Journal title:
physiology and pharmacology

جلد ۱۵، شماره ۴، صفحات ۴۹۹-۵۰۶

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023